1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease
US6414153B1 · kind B1 · utility
22Cited by
12References
14Claims
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Key dates
| Filing date | Jun 28, 2000 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Jun 28, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are:3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one;3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one;3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one;3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and,3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.