Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine
US6416735B1 · kind B1 · utility
19Cited by
3References
13Claims
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Key dates
| Filing date | Nov 8, 1999 |
| Grant date | Jul 9, 2002 |
| Priority date | — |
| Expiry date | Nov 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0455
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimer's and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.