Method for modulating apoptosis
US6416753B1 · kind B1 · utility
8Cited by
7References
9Claims
0Family size
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Key dates
| Filing date | Mar 13, 1997 |
| Grant date | Jul 9, 2002 |
| Priority date | — |
| Expiry date | Mar 13, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for modulating programmed cell death are provided. Apoptosis, induced by a variety of stimuli, can be inhibited by blocking IL-1&bgr; binding to its type-1 receptor. Additionally, IL-1&bgr; had anti-apoptotic activity when added exogenously prior to exposure to apoptotic stimuli. ICE cleavage of pro-IL-1&bgr; is an important step in apoptosis, and mature IL-1&bgr; may function as a positive or negative mediator of cell death.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.