Vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPS)
US6416945B1 · kind B1 · utility
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Key dates
| Filing date | Aug 24, 1999 |
| Grant date | Jul 9, 2002 |
| Priority date | — |
| Expiry date | Aug 24, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or “marker” DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.
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