Detection and visualization of neoplastic tissues and other tissues
US6416960B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 8, 1997 |
| Grant date | Jul 9, 2002 |
| Priority date | — |
| Expiry date | Aug 8, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems are particularly useful for visualizing and detecting neoplastic tissue and specialty tissue during surgical procedures. Kits that provide the components of the systems and methods using the systems for visualizing the tissue are also provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal. Therapeutic methods in which photosensitizing compounds are administered are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.