Arylalkanoylpyridazines

US6417188B1 · kind B1 · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Michael Wolf · Darmstadt, DE
• Franz-Werner Kluxen · Darmstadt, DE

Key dates

• Filing date: Dec 13, 2000
• Grant date: Jul 9, 2002
• Expiry date: Dec 13, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D237/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Arylalkanoylpyridazine derivatives of the formula I and their physiologically acceptable salts and solvates,in whichR1, R2, Q and B have the meanings indicated in Claim 1, show an inhibition of phosphodiesterase IV and can be employed for the treatment of asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune disorders, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth or tumor metastases, sepsis, memory disorders, atherosclerosis and AIDS.