Process for the preparation of beta hydroxy-delta lactone using novel intermediates

US6417374B1 · kind B1 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Sandeep Raghunath Ghorpade · Jamkhed, IN
• Uttam Ramrao Kalkote · Jamkhed, IN
• Subhash Prataprao Chavan · Jamkhed, IN
• Sunil Ramchandra Bhide · Jamkhed, IN
• Thottappillil Ravindranathan · Jamkhed, IN

Key dates

• Filing date: Feb 15, 2001
• Grant date: Jul 9, 2002
• Expiry date: Feb 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/188
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(&bgr;-Hydroxy-&dgr;-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.