Process for preparing enantiomer-enriched amino- and hydroxyfuranones

US6417377B1 · kind B1 · utility

Assignee

• DSM Fine Chemicals Austria NFG GmbH & Co KG · AT

Inventors

• Peter Pochlauer · Dordrecht, NL
• Peter Riebel · Kaiseraugst, CH
• Herbert Mayrhofer · Linz, AT
• Irma Wirth · Ansfelden, AT

Key dates

• Filing date: Jan 15, 2002
• Grant date: Jul 9, 2002
• Expiry date: Jan 15, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/66
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of enantiomer-enriched aminofuranones and hydroxyfuranones in which an enantiomer-enriched cyanohydrin is acylated by an acylating agent, then cyclized at 40 to 90° C. in the presence of zinc or a zinc compound to the corresponding enantiomer-enriched aminofuranone, which is converted where appropriate by acid hydrolysis into the corresponding enantiomer-enriched hydroxyfuranone.