Chemical synthesis using solvent microdroplets
US6419883B1 · kind B1 · utility
95Cited by
29References
95Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 16, 1998 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Jan 16, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to microdroplets of a solution comprising a solvent having a boiling point of 150° C. or above, a surface tension of 30 dynes/cm or above, and a viscosity of 0.015 g/(cm)(sec). Such microdroplets are useful for the synthesis of chemical species, particularly biopolymers such as oligonucleotides and peptides, as well as arrays of chemical species. Preferably, the solvent has the formula (I): whereinA=O or S;X=O, S or N (C1-C4 alkyl)Y=O, S, N(C1-C4 alkyl) or CH2; andR=C1-C20 straight or branched chain alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.