Patent · US Expired

Human pluripotent hematopoietic colony stimulating factor, method of use

US6419918B1 · kind B1 · utility

2Cited by

7References

2Claims

0Family size

Assignee

Sloan Kettering Institute for Cancer Research · US

Inventors

Karl Welte · New York, US
Erich Platzer · Erlangen, DE
Janice L. Gabrilove · New York, US
Roland Mertelsman · Mainz, DE
Malcolm A. S. Moore · New York, US

Key dates

Filing date	Jun 5, 2000
Grant date	Jul 16, 2002
Priority date	—
Expiry date	Jun 5, 2020

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Highly purified Pluripotent hematopoietic colon-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparent homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM) early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5×108 U/mg protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.