Compositions and methods for eliciting CTL immunity
US6419931B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1994 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Feb 16, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Cocktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class I restricted coverage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.