Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections

US6420127B1 · kind B1 · utility

Assignees

• Washington University · US
• SIGA Pharmaceuticals, Inc. · US

Inventors

• Scott Hultgren · Ballwin, US
• Meta Kuehn · Berkeley, US
• Zheng Xu · Vienna, US
• Derek Ogg · Uppsala, SE
• Mark Harris · Uppsala, SE
• Matti Lepisto · Lund, SE
• Charles Hal Jones · Chesterfield, US
• Jan Kihlberg · Mölnlycke, SE

Key dates

• Filing date: Oct 10, 1996
• Grant date: Jul 16, 2002
• Expiry date: Oct 10, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/849
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.