Patent · US Expired

Process for the preparation of D-asparagine derivatives

US6420166B2 · kind B2 · utility

1Cited by

2References

8Claims

0Family size

Assignee

Basolea Pharmaceutica AG · CH

Inventors

Hans Iding · Rheinfelden (Baden), DE
Mark Rogers-Evans · Bottmingen, CH
Beat Wirz · Basel, CH

Key dates

Filing date	Apr 12, 2001
Grant date	Jul 16, 2002
Priority date	—
Expiry date	Apr 12, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P17/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides a process for the preparation of D-asparagine derivatives of formula I wherein R1 is an amino protecting group and R2 is an alkyl, a substituted alkyl or a group of formula AR3(OCH2CH2)n—  Awherein R3 is hydrogen or an lower alkyl group and n is 1, 2 or 3, which process comprises reacting a compound of formula II wherein R1 and R2 are as defined above, with a protease in an aqueous solution at a pH of 6.0-7.5 and an organic solvent, and subsequently extracting the enantiomeric pure product of formula I. Compounds of formula I can be used as intermediates in the production of antibacterial substances.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.