Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6420377B1 · kind B1 · utility
6Cited by
28References
8Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 28, 2000 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Nov 28, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I:TI—L—TII  (I)wherein:TI is a topoisomerase I inhibitor such as a camptothecin group;TII is a topoisomerase II inhibitor such as an amsacrine, ellipticine, epipodophyllotoxin, or anthracycline antibiotic group; andL is a linking group.The compounds are useful for inhibiting topoisomerase I and II enzymes, for promoting cellular differentiation, and for treating cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.