Biphenyl and biphenyl-analogous compounds as integrin antagonists

US6420396B1 · kind B1 · utility

Assignee

• BEIERSDORF AG · DE

Inventors

• Markus Albers · Leverkusen, DE
• Klaus Urbahns · Kasai, JP
• Andrea Vaupel · Riehen, CH
• Michael Härter · Wixom, US
• Delf Schmidt · Wuppertal, DE
• Beatrix Stelte-Ludwig · Wülfrath, DE
• Christoph Gerdes
• Elke Stahl · Bensberg, DE
• Jörg Keldenich · Wuppertal, DE
• Ulf Brueggemeier · Madison, US
• Klemens Lustig · Wuppertal, DE

Key dates

• Filing date: Dec 15, 1999
• Grant date: Jul 16, 2002
• Expiry date: Dec 15, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to 2-Mesitylsulfonylamino-3-{3′[(pyridinylamino)methyl][1,1-biphenyl]-4-yl}propanoic acid, pharmaceutical compositions thereof, their preparation, their use in the treatment of cancer, arteriosclerosis, restenosis, osteolytic disorders, ophthalmic disorders, and their use as integrin antagonists. The compounds according to the invention have the formula (I):