Genetic selection method for identifying ligands for transmembrane proteins
US6420529B1 · kind B1 · utility
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7Claims
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Key dates
| Filing date | Mar 5, 1998 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Mar 5, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A chimeric protein having an (a) IRE1 or analog cytoplasmic kinase domain, (b) a transmembrane domain, and (c) a ligand binding domain of a transmembrane protein other than IRE1 is described. This protein can be used to identify and/or screen for ligands and other molecules that interact with the ligand binding domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.