Alzheimer's disease secretase, APP substrates therefor, and uses thereof
US6420534B1 · kind B1 · utility
32Cited by
19References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 2000 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Apr 12, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96472
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.