Processes for preparing 3-arylsulfur hydroxamic acids

US6420573B1 · kind B1 · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Jeffrey Allen Campbell · Cheshire, US
• Lawrence Emerson Fisher · Mountain View, US
• Charles Alois Dvorak · Palo Alto, US
• Paul McGrane · Sioux Falls, US

Key dates

• Filing date: Nov 9, 2001
• Grant date: Jul 16, 2002
• Expiry date: Nov 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides processes for the preparation of a compound of Formula I:Y—C(═O)—C(R1)(R2)—CH2—S(O)nR3wherein:Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl or lower acyl;R1 is hydrogen or lower alkyl;R2 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, or R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl or heterocyclo group;R3 is aryl; andn is 0, 1 or 2.The invention also provides novel aryl haloalkyl sulfide intermediates useful for the preparation of compounds of Formula I and novel methods of preparing aryl alkyl sulfides.