Process for producing solid dosage forms

US6423256B1 · kind B1 · utility

Assignee

• BASF SE

Inventors

• Stephan Kothrade · Schifferstadt, DE
• Jorg Breitenbach · Mannheim, DE
• Harald Krull · Ludwigshafen, DE
• Thomas Kessler · Schifferstadt, DE
• Armin Lange · Heidelberg, DE
• Werner Maier · Schifferstadt, DE
• Ulrich Reinhold · Heidelberg, DE

Key dates

• Filing date: Oct 13, 1999
• Grant date: Jul 23, 2002
• Expiry date: Oct 13, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2095
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.