Process for the preparation of a solid pharmaceutical dosage form
US6423342B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 4, 1999 |
| Grant date | Jul 23, 2002 |
| Priority date | — |
| Expiry date | May 4, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for the preparation of a solid pharmaceutical dosage form comprising a carrier and, as active ingredient, a compound which exists, in solution, in an equilibrium between a free acid or free base form and a salt form, and for which there is a difference in volatility between the free acid or free base form and the salt form. The process includes the steps of solidifying a mixture of the compound and carrier in a solvent, and subsequently removing the solvent from the solidified mixture. A pH modifier is added to the mixture prior to solidification to shift the equilibrium to favor the less volatile form of the active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.