Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena

US6423516B1 · kind B1 · utility

Assignee

• EVOTEC BIOSYSTEMS GMBH · DE

Inventors

• Manfred Eigen · Göttingen, DE
• Andreas Schwienhorst · Göttingen, DE
• Christof Biebricher · Dransfeld, DE
• Björn F. Lindemann · Göttingen, DE
• Esteban Domingo · Colmenar Viejo, ES
• John E. Holland · Bailey, US
• Karsten Henco · Erkrath, DE

Key dates

• Filing date: Mar 22, 1996
• Grant date: Jul 23, 2002
• Expiry date: Mar 22, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/143333
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system,a)whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and,whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus,b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.