Method of inducing formation of kidney epithelia from mesenchymal precursors

US6423681B1 · kind B1 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jonathan Barasch · New York, US
• Juan Oliver · New York, US
• Jun Yang · Shanghai, CN

Key dates

• Filing date: May 4, 1999
• Grant date: Jul 23, 2002
• Expiry date: May 4, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/237
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods of using a gpl3O receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.