Nitroimidazole ester analogues and therapeutic applications
US6423707B1 · kind B1 · utility
4Cited by
13References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 2000 |
| Grant date | Jul 23, 2002 |
| Priority date | — |
| Expiry date | Aug 28, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These nitroimidazole ester analogs have anti-microbial activity, with a number of novel compounds having an anti-microbial activity that is significantly improved with respect to metronidazole. Two particularly preferred embodiments are shown by Formulas 4 and 5 below:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.