Benzamidoxime prodrugs as antipneumocystic agents
US6423737B1 · kind B1 · utility
3Cited by
13References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jan 12, 2001 |
| Grant date | Jul 23, 2002 |
| Priority date | — |
| Expiry date | Jan 12, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.