Process for the preparation of trifluorothymidine derivatives
US6423852B1 · kind B1 · utility
1Cited by
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30Claims
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Key dates
| Filing date | Oct 9, 2001 |
| Grant date | Jul 23, 2002 |
| Priority date | — |
| Expiry date | Oct 9, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine is reacted with a 2-deoxy-&agr;-D-erythro-pentofuranosyl chloride derivative reacted in the absence or presence of a small amount of solvent to give a &bgr;-form of 1-(2′-deoxy-&bgr;-D-erythro-pentofuranosyl)-5-trifluoromethyl uracil derivative with a high selectivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.