Cell encapsulating device containing a cell displacing core for maintaining cell viability
US6426214B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1999 |
| Grant date | Jul 30, 2002 |
| Priority date | — |
| Expiry date | Nov 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0085
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. A preferred device contains a polytetrafluoroethylene permeable membrane and a flexible polymer core having a plurality of ridges and valleys running lengthwise along the core. The cell zone may contain support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.