Automatic sequencer/genotyper having extended spectral response
US6427126B1 · kind B1 · utility
1Cited by
18References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 8, 1999 |
| Grant date | Jul 30, 2002 |
| Priority date | — |
| Expiry date | Jan 8, 2019 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00702
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An advanced imaging spectrograph system and method are provided for very high throughput identification, sequencing and/or genotyping of DNA and other molecules. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.