Method of producing sub-micron particles of biologically active agents and uses thereof

US6428815B1 · kind B1 · utility

Assignee

• Alkermes Controlled Therapeutics, Inc. · US

Inventors

• Henry R. Costantino · Woodinville, US
• Warren Jaworowicz · Boxboro, US
• Mark Tracy · Arlington, US
• Christopher P. Beganski · Littleton, US

Key dates

• Filing date: Jul 3, 2001
• Grant date: Aug 6, 2002
• Expiry date: Jul 3, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2985
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen droplets to obtain microstructures capable of being further fragmented into submicron particles by techniques such as probe sonication. The submicron particles can be incorporated into sustained release compositions having a reduced initial release of biologically active agent. The sustained release compositions can be administered to a human or animal.