Endometriosis mouse model

US6429353B1 · kind B1 · utility

Assignees

• Reprogen, Inc. · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Jeffrey Boyd · New York, US
• Jerome J. Strauss · Whitemarsh, US
• Peter Van Deerlin · Lansdowne, US
• Karen K. Yamamoto · San Clemente, US

Key dates

• Filing date: Mar 25, 1998
• Grant date: Aug 6, 2002
• Expiry date: Mar 25, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2267/03
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides an endometriosis mouse model wherein severely compromised immune deficient (SCID) female mice are transplanted with human xenografts of normal endometrial tissue, but result in mice with human endometriosis. Typically, the xenografts are treated with a micronized estrogen source prior to transplantation or implantation and the endogenous progesterone of the mice is eliminated also prior to transplantation of the human xenograft. These diseased mice are useful in the study of endometriosis.