Isolated CYP3A4 nucleic acid molecules and detection methods
US6432639B1 · kind B1 · utility
14Cited by
8References
15Claims
0Family size
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Key dates
| Filing date | Aug 31, 1998 |
| Grant date | Aug 13, 2002 |
| Priority date | — |
| Expiry date | Aug 31, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Genetic polymorphisms are identified in the human CYP3A4 gene that alter CYP3A4-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for CYP3A4 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.