17a-hydroxy-4-androstene-3-one and derivatives thereof

US6432939B1 · kind B1 · utility

Inventors

• Michael Oettel · Jena, DE
• Jens Berlau · Erfurt, DE
• Wolfgang Romer · Jena, DE
• Gerhard Schreiber · Jena, DE

Key dates

• Filing date: Nov 10, 2000
• Grant date: Aug 13, 2002
• Expiry date: Nov 10, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention describes 17&agr;-hydroxy-4-androstene-3-one and its derivatives of the general formula I a method for producing these compounds and pharmaceuticals containing these compounds. The compounds according to the invention can be used for regulating spermatogenesis and for hormone replacement therapy in males by stimulating the inhibin-B secretion by the Sertoli cells. The increased inhibin-B concentration suppresses spermatogenesis in the testicles as it inhibits excretion by the hypophysis of follicle-stimulating hormone (FSH) that is essential in spermatogenesis.