2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype specific ligands
US6432958B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 29, 2001 |
| Grant date | Aug 13, 2002 |
| Priority date | — |
| Expiry date | Aug 29, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the formula: or pharmaceutically acceptable salts thereof, wherein:A is (un)substituted alkylene;R1 and R2 are the same or different and represent hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, (un)substituted amino, cyano, nitro, sulfonamide, trifluoromethyl or trifluoromethoxy;R3, R4, R5, R6, and R8 are independently hydrogen or alkyl; andX is sulfur, oxygen or NR7 where R8 is defined herein;m is an integer chosen from 0, 1 or 2; andAr is an aryl or heteroaryl group as further defined herein,which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.