Inhibitors of farnesyl-protein transferase

US6432959B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Alan B. Cooper · West Caldwell, US
• Ronald J. Doll · Maplewood, US
• Johan Ferreira · Bethlehem, US
• Ashit K. Ganguly · Upper Montclair, US
• Viyyoor M. Girijavallabhan · Parsippany, US
• Arthur G. Taveras · Rockaway, US
• Jianping Chao · Summit, US
• John J. Baldwin · Gwynedd Valley, US
• Chia-Yu Huang · Princeton Junction, US
• Ge Li · Shanghai, CN

Key dates

• Filing date: Dec 22, 1999
• Grant date: Aug 13, 2002
• Expiry date: Dec 22, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.