Pyrazolecarboxylic acid derivatives, their preparation, pharmaceutical compositions containing them

US6432984B1 · kind B1 · utility

Assignee

• Sanofi-Synthelabo · FR

Inventors

• Francis Barth · Juvignac, FR
• Philippe Camus · Muret, FR
• Serge Martinez · Montpellier, FR
• Murielle Rinaldi · Juvignac, FR

Key dates

• Filing date: Jul 27, 2001
• Grant date: Aug 13, 2002
• Expiry date: Jul 27, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C251/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.