Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action

US6432987B1 · kind B1 · utility

Assignee

• Zentaris GmbH · DE

Inventors

• Eckhard Gunther · Offenbach, DE
• Peter Emig
• Dietmar Reichert · Eschau, DE
• Guillaume Le Baut · Saint-Sébastien-sur-Loire, FR
• Bernd Nickel · Mühltal, DE
• Gerald Bacher · Heidelberg, DE

Key dates

• Filing date: Dec 15, 2000
• Grant date: Aug 13, 2002
• Expiry date: Dec 15, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides. In addition, the invention relates to pharmaceutical preparations containing at least one of the compounds of the abovementioned formula or their salts or N-oxides with physiologically tolerable inorganic or organic acids and, if appropriate, pharmaceutically utilizable vehicles and/or diluents or excipients and also administration forms of the compounds of the abovementioned formula containing at least one of the compounds of this formula or their salts in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments