Indane compounds and their pharmaceutical use

US6433021B1 · kind B1 · utility

Assignee

• Venantius Limited · IE

Inventors

• Neil Frankish · Dublin, IE
• Helen Sheridan · Dublin, IE
• John Walsh · Ballinrobe, IE
• Michael Jordan · Denver, US

Key dates

• Filing date: Dec 3, 1999
• Grant date: Aug 13, 2002
• Expiry date: Dec 3, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C49/798
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, cyclopentyl, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxyamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, indane, indene, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitirile, heterocyclic groups containing hetero atoms selected from one or more of N, O or S, aralkyl groups, aryl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, carboxylic acid groups of C1 to C10 which may be substituted or unsubstituted, alkyl, substituted alkyl groups, acyl groups, substituted acyl groups; where R1 and R3 may together represent a double bond and wherein in (CH2)n, n is 0 to 8.