Preparation of 6-&agr;-hydroxy-7-deoxytaxanes using nocardioides luteus or a hydroxylase isolated therefrom
US6433198B1 · kind B1 · utility
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Key dates
| Filing date | Jul 13, 2000 |
| Grant date | Aug 13, 2002 |
| Priority date | — |
| Expiry date | Jul 15, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6-&agr;-hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.