Alpha-substitution of unprotected &bgr;-amino ester compounds
US6433209B1 · kind B1 · utility
1Cited by
3References
22Claims
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Key dates
| Filing date | Jan 26, 2000 |
| Grant date | Aug 13, 2002 |
| Priority date | — |
| Expiry date | Jan 26, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for stereoselective substitution in which a (mono or un)-&agr;-substituted unprotected &bgr;-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.