Method for determination of chromatographic media parameters in packed beds of hydrophobic polymer particles
US6435012B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 7, 2001 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Aug 7, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/89
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
An improved method for measuring the chromatographic properties, such as excluded volume, of hydrophobic polymer substrates is disclosed. Use of 0.05-1 micron sized crosslinked ionically-charged polymer particles, especially emulsion-form or ground polymer particles, as a large-molecule probe, allows environmentally friendly aqueous-based solvent systems to be used as mobile phases to characterize hydrophobic polymer supports for use in analytical or preparative scale chromatographic applications. This method eliminates the use of non-polar organic solvents that is required when conventional non-polar large-molecule probes (such as polystyrene) are used to characterize chromatographic media.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.