Micro-machined calorimetric biosensors
US6436346B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1999 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Sep 14, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01K17/006
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.