Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
US6436386B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2000 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Nov 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.