Mutant enterotoxin effective as a non-toxic adjuvant
US6436407B1 · kind B1 · utility
7Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1999 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Aug 4, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This enterotoxin is used in combination with an unrelated antigen to achieve an increased immune response to said antigen when administered as part of a vaccine preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.