DNA encoding neospora dihydrofolate reductase-thymidylate synthase
US6436410B1 · kind B1 · utility
2Cited by
4References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 2, 1998 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Dec 2, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides isolated polynucleotide molecules comprising a nucleotide sequence encoding the DHFR-TS protein of Neospora which polynucleotide molecules are useful in preparing modified live vaccines against neosporosis, and as diagnostic reagents. The present invention further provides cloning and expression vectors, transformed host cells, substantially purified DHFR-TS proteins and peptide fragments, genetic constructs useful for targeted gene deletion, and vaccine compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.