Method for detecting chemical interactions between naturally occurring biological analyte molecules that are non-identical binding partners
US6436647B1 · kind B1 · utility
27Cited by
3References
24Claims
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Key dates
| Filing date | Mar 19, 2001 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Mar 19, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/958
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners is provided. The method is useful whether the reactions occur through electrostatic forces or other forces. Induced stress, heat, or change in mass is detected where a binding partner is placed on a cantilever for possible reaction with an analyte molecules (i.e., a non-identical binding partner). The method is particularly useful in determining DNA hybridization but may be useful in detecting interaction in any chemical assay.
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