Non-estrogenic estradiol derivative compounds with anti-oxidative activity

US6436917B1 · kind B1 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Peter Droescher · Weimar, DE
• Bernd Menzenbach · Jena, DE
• Wolfgang Roemer · Jena, DE
• Birgitt Schneider · Jena, DE
• Walter Elger · Berlin, DE
• Guenter Kaufmann · Jena, DE

Key dates

• Filing date: Jun 5, 1998
• Grant date: Aug 20, 2002
• Expiry date: Jun 5, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J31/006
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, especially for administration in post-menopausal women and in men. The compounds of the invention can also inhibit aromatase and sulfatase.