Trans cyclopentanyl purine analogs useful as immunosuppressants
US6436947B1 · kind B1 · utility
1Cited by
16References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 1997 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Nov 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) whereinthe substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,Y3, Y5 Y7, Y9 are each nitrogen and Y8 is a CH group,R is a hydrogen, a C1-C7 alkyl acyl or aryl acyl,Q is NH2, halogen or hydrogen,Z is hydrogen, halogen, or NH2;or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.