Camptothecin tetracyclic analogues, preparation, method, applications as medicines and pharmaceutical compositions containing them

US6436951B1 · kind B1 · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Dennis Bigg · Gif-sur-Yvette, FR
• Olivier Lavergne · Palaiseau, FR
• Alain Rolland · Palaiseau, FR
• Christophe Lanco · Étampes, FR
• Gerard Ulibarri · Les Ulis, FR

Key dates

• Filing date: Jun 20, 2000
• Grant date: Aug 20, 2002
• Expiry date: Jun 20, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity inhibiting topoisomerase I and/or topoisomerase II.