Use of RAR antagonists as modulators of hormone mediated processes
US6436993B1 · kind B1 · utility
4Cited by
35References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 13, 1999 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Jul 13, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, it has been discovered that retinoic acid receptor (RAR) antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs (e.g., PPAR&agr;, PPAR&dgr; and PPAR&ggr;). Indeed, it has been discovered that RAR antagonists, in combination with agonists for members of the steroid/thyroid hormone receptor superfamily, are capable of inducing and/or enhancing processes mediated by such members.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.