Thiazolidone-2 derivatives, 4-diketone substituted, method for obtaining them and pharmaceutical compositions containing same
US6437143B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 7, 1998 |
| Grant date | Aug 20, 2002 |
| Priority date | — |
| Expiry date | Dec 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P39/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry.The subject of the present invention is more precisely new 5-phenoxyalkyl-2,4-thiazolidinediones of general formula I: in whichA represents a linear or branched alkylene group comprising from 2 to 16 carbon atomsD represents a homo- or heterocarbon mono-, di- or tricyclic aromatic structure which may include one or more heteroatomsX represents the substituent of the aromatic structure and is as defined in Claim 1n is an integer ranging from 1 to 3with the proviso that if A represents a butyl radical,  does not represent the 4-chlorophenyl group.The invention also relates to the tautomeric forms, to the enantiomers, diastereoisomers and epimers of the compounds of general formula I, in free or salified form.The present invention also relates to the processes for producing the compounds of general formula I, their use as antidiabetic agents, and in the treatment of the metabolic syndrome of insulin resistance, as well as the pharmaceutical compositions which contain the compounds of general formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.