Method of producing oxazolidinones, the use thereof and oxazolidinones

US6437145B1 · kind B1 · utility

Assignee

• Degussa-Huels AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Gunter Knaup · Bruchköbel, DE
• Stefan Retzow · Alzenau, DE

Key dates

• Filing date: Apr 4, 2000
• Grant date: Aug 20, 2002
• Expiry date: Apr 4, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns a method of producing oxazolidinones of formula (I), wherein R1-R5 have the meanings given in the description, by reacting cyclical anhydrides of formula (II) with carbonyl compounds of general formula (III) at temperatures between ambient temperature and approximately 150° C. The invention also concerns the production of the cyclical anhydrides of formula (II) by reacting N-protected aminodicarboxylic acids of formula (IV) with a dehydrating agent in situ. The invention further concerns the use of oxazolidinones of formula (I) for the &agr;-selective production of esters of formula (V) and amides of general formula (VII).